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Further, despite the persistent notion that all diuretics might have diabetogenic properties, long-term studies in preclinical animal models are still missing and many questions remain unanswered regarding the mechanisms whereby these drugs may exert their metabolic effects under different chronic contexts

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Abstract Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a naturally occurring polyphenol molecule

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We further discuss emerging advances in omics, spatial biology, genome editing and artificial intelligence that enable deeper mapping and predictive modeling of proteostasis networks, paving the way toward personalized, mechanism-based interventions